BioSolutions Halle GmbH

An-Institut der Martin-Luther-Universität Halle-Wittenberg BioSolutions Halle GmbH, Weinbergweg 22, 06120 Halle

 

René Csuk, Alexander Barthel, Stefan Schwarz, Harish Kommer and Reinhard Paschke, Synthesis and biological evaluation of antitumor-active gamma-butyrolactone substituted betuline derivatives, Bioorganic & Medicinal Chemistry, in press

Harish Kommera, Goran N. Kaluderovic, Martin Bette, Jutta Kalbitz, Petra Fuchs, Simone Fulda, Walter Mier and Reinhard Paschke, In vitro anticancer studies of a- and ß-D-glucopyranose betulin anomers, Chemico-Biological Interactions, in press

Harish Kommera, Goran N. Kaluderovic, Jutta Kalbitz and Reinhard Paschke, Synthesis and Anticancer Activity of Novel Betulinic acid and Betulin Derivatives, Archiv der Pharmazie, in press

Harish Kommera, Goran N. Kaluderovic, Jutta Kalbitz and Reinhard Paschke, Lupane Triterpenoids – Betulin and Betulinic acid derivatives induce apoptosis in tumor cells, Investigational New Drugs, in press

Csuk, Rene; Barthel, Alexander; Kluge, Ralph; Stroehl, Dieter; Kommera, Harish; Paschke, Reinhard; Synthesis and biological evaluation of antitumour-active betulin derivatives; Bioorganic & Medicinal Chemistry (2010), 18(3), 1344-1355

Gómez-Ruiz, S., Prashar, S., Walther, T., Fajardo, M., Steinborn, D., Paschke, R. and Kaluderovic, G. N., Cyclopentadienyl tin(IV) derivatives; synthesis, characterization and study of their application as anticancer drugs. Polyhedron 29 (2010) 16–23

Milena R. Kaluderovic, Santiago Gomez-Ruiz, Beatriz Gallego, Evamarie Hey-Hawkins, Reinhard Paschke, Goran N. Kaluderovic, Anticancer activity of dinuclear gallium(III) carboxylate complexes, European Journal of Medicinal Chemistry 45 (2010) 519–525

Kaluderovic, G. N., Kommera, H., Schwieger, S., Paethanom, A., Kunze, M., Schmidt, H., Paschke, R. and Steinborn, D., Synthesis, characterization, in vitro antitumoral investigations and interaction with plasmid pBR322 DNA of R2eddp-platinum(IV) complexes (R = Et, n-Pr). Themed Issue “Metal containing compounds with anticancer properties” Dalton Trans. (2009), 10720-10726

Vetter, C., Kaluderovic, G. N., Paschke, R., Gómez-Ruiz, S. and Steinborn, D.: Synthesis, structures and in vitro cytotoxicity studies of platinum(IV) complexes with N,S and S,S heterocyclic ligands. Polyhedron,(2009), 28(17), 3699-3706

Santiago Gómez-Ruiz, Dorian Polo-Cerón, Valentina Tayurskaya , Sanjiv Prashar, Mariano Fajardo, Reinhard Paschke, A novel alkenyl-substituted
ansa-zirconocene complex with dual application as olefin polymerization catalyst and anticancer drug, Journal of Organometallic Chemistry,(2009), 694(18), 3032-3038.

Gómez-Ruiz, S., Gallego, B., Kaluderovic, M. R., Kommera, H., Hey-Hawkins, E., Paschke, R. and Kaluderovic, G. N. (2009): Novel Gallium(III) complexes containing phthaloyl derivatives of neutral aminoacids with apoptotic activity in cancer cells. Journal of Organometallic Chemistry (2009), 694(14), 2191-2197

M. Willmann, V. Wacheck, J. Buckley, K. Nagy, J. Thalhammer, R. Paschke,T. Triche, B. Jansen, and E. Selzer; Characterization of NVX-207, a novel betulinic acid-derived anti-cancer Compound, European Journal of Clinical Investigation, Volume 39, Issue 5, 2009, 384-394.

Bojana B. Zmeijkovski, Goran N. Kaluderovic, Santiago Gómez-Ruiz, Željko Žižak, Dirk Steinborn, Harry Schmidt, Reinhard Paschke, Zorica D. Juranic and Tibor J. Sabo Palladium(II) complexes with R2edda derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R2eddip esters and palladium(II) complexes, Europ.J.Med.Chem.(2009) 44(9), 3452-3458.

Vetter, C.; Wagner, C.; Kaluderovic, G. N.; Paschke, R.; Steinborn, D. Synthesis, characterization, and cytotoxicity of trimethylplatinum(IV) complexes with 2-thiocytosine and 1-methyl-2-thiocytosine ligands. Inorg.Chim.Acta 362[1], 189-195. 2009.

Kelly, M. E.; Dietrich, A.; Gomez-Ruiz, S.; Kalinowski, B.; Kaluderovic, G. N.; Mueller, T.; Paschke, R.; Schmidt, J.; Steinborn, D.; Wagner, C.; Schmidt, H. Platinum(IV) Metallacrown Ethers: Synthesis, Structures, Host Properties and Anticancer Evaluation. Organometallics 27[19], 4917-4927. 2008.

Dietrich, A.; Mueller, T.; Paschke, R.; Kalinowski, B.; Behlendorf, T.; Reipsch, F.; Fruehauf, A.; Schmoll, H. J.; Kloft, C.; Voigt, W. 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II): A Novel Platinum Compound that Overcomes Cisplatin Resistance and Induces Apoptosis by Mechanisms Different from that of Cisplatin. J.Med.Chem. 51[17], 5413-5422. 2008.

Kaluderovic, G. N.; Schmidt, H.; Schwieger, S.; Wagner, C.; Paschke, R.; Dietrich, A.; Mueller, T.; Steinborn, D. Platinum(IV) complexes with ethylenediamine-N,N'-diacetate diester (R2edda) ligands: Synthesis, characterization and in vitro antitumoral activity. Inorg.Chim.Acta 361[5], 1395-1404. 2008.

Lindner, R.; Kaluderovic, G. N.; Paschke, R.; Wagner, C.; Steinborn, D. Synthesis and characterization of dinuclear pyrazolato bridged platinum(IV) complexes. Polyhedron 27[3], 914-922. 2008

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